Parmar and others published hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in wistar rats find, read and cite all the. The ic 50 of the ethanolic extract was found to be 72. The plant can be identified authenticated by department of botany, research office botanist. The water extracts showed a hepatoprotective effect against ccl. Thirtysix rats were randomly divided into six groups of 6 replicates.
Plant extracts were serially diluted, ranging from 12 up to a 1100 dilution from the crude extract. Additional studies are in progress to better understand the mechanism of action of lle that is responsible for the hepatoprotective and antioxidant effects. Hepatoprotective activity of ethanolic extract of salix subserrata. Further isolation of the active principles responsible for its hepatoprotective activity is currently in progress within our laboratory. A number of plantbased traditional medicines or formulations containing herbal extracts are sold in the market for liver disorders, especially in countries like india. Paracetamolinduced liver injury was used as in vitro reference standard. Biochemical parameters including serum transaminases aspartate aminotransferase ast and alanine aminotransferase alt and alkaline phosphatase alp in serum were analyzed. Presl whole plant possesses hepatoprotective activity against paracetamol induced hepatotoxicity. Although many plant extracts have been studied, many others have not, therefore, a special issue on the pharmacology of plant extracts is timely. Jaya raju, investigation of hepatoprotective activity of spondias pinnata, international journal of pharma sciences and research, vol. The hepatoprotective and antioxidant activity of aqueous and methanolic extracts of pseudocedrela kotschyi stem bark was confirmed by biochemical, antioxidant and histopathological studies.
It is involved with almost all the biochemical pathways. Silymarin as a standard drug for comparing the activity. Plant extracts of many crude drugs are also used for the treatment of. Natural remedies from medicinal plants are considered to be effective and safe alternative treatment for liver injury. In vitro hepatoprotective activity of the extract was evaluated at 20, 40, 60, 80 and 100 microgml concentration against ccl4 1% induced toxicity in freshly isolated rat hepatocytes. Methanolic solution of plant extracts and ascorbic acid were prepared at 31. Research article open access hepatoprotective effect of. Pdf hepatoprotective activity of methanolic extract of. Therefore, it is also possible to postulate that extracts compounds possessing antiinflammatory activity might also exhibit hepatoprotective activity.
Tanninrich extracts from lannea stuhlmannii and lannea humilis anacardiaceae exhibit hepatoprotective activities in vivo via enhancement of the anti. In addition, different extracts of the plant were examined for their hepatoprotective activity against cc1 4induced hepatotoxicity in albino rats. Hepatoprotective activity of the ethanolic extract of ficus caricalinn. The hepatoprotective potentials of the methanol aerial part mme and root rme extracts of schwenckia americana linn solanaceae against carbon tetrachloride ccl4induced hepatotoxicity in. Hepatoprotective activity of alcoholic and aqueous extracts.
The antimicrobial activity of hot water and ethanolic extracts of six plant extracts, utilized in pakistan for the cure of liver damage, were studied. Amongst the active plant extracts, the crude methanol extract of m. The current study investigates phytochemical constituents, antioxidant and hepatoprotective activity of solvent extracts of whole plant of viola canescens. Hepatoprotective activity of aqueous and methanolic extracts. The antiibv activity prior to infection in vero cells the inhibitory effect of extracts against ibv prior to infection in vero cells was measured by virus plaque and tcid 50 assays. In india, numerous medicinal plants are used for the treatment of liver disorders. Antimicrobial activity of some plant extracts having.
The hepatoprotective activity is probably due to the presence of flavonoids, phenolic compounds, polyphenols etc in all few herbal plants. Antioxidant and hepatoprotective activity of methanolic and. The hepatoprotective effect of the extract of the stem of the plant 200600 mgkg was evaluated by the assay of liver function parameters, namely total and direct bilirubin, serum protein and albumin, total cholesterol, alanine aminotransaminase alt, aspartate aminotransaminase ast, and alkaline phosphatase activities alp, antioxidant enzymes like superoxide dismutase sod, catalase cat, and glutathione peroxidase gpx, reduced glutathione gsh and histopathological study of the. The biological and hepatoprotective activity of plant extracts defends. References adje f, lozano yf, meudec e, lozano p, adima a, gaydou em. Therefore, it is also possible to postulate that extractscompounds possessing antiinflammatory activity might also exhibit hepatoprotective activity. Result indicate that the plant good potential to act as hepatoprotective agent. Hepatoprotective effect of aqueous extracts of some. Pdf medicinal plants possessed hepatoprotective activity. Medicinal plants are still a potent source of therapeutic agent. The present pharmacological investigation focuses on evaluation of the efficacy of aqueous extract of roots of amaranthus tricolor linn. There is no previous study for hepatoprotective activity for f. There is area for further study to characterize the active principle responsible for the hepatoprotective activity of. Pdf hepatoprotective activity of some plants extract.
With a view that sterols, flavonoids, furanocoumrains and triterpens found in medicinal plants are used as hepatoprotective drugs 11, it was thought worthwhile to. The hepatoprotective potentials of the methanol aerial part mme and root rme extracts of schwenckia americana linn solanaceae against carbon tetrachloride ccl4induced hepatotoxicity in rats was studied. Parmar and others published hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in wistar. The hepatoprotective activity of these extracts in carbon tetrachloride ccl4, 0. The hepatoprotective activity of lle may be due to its free radicalscavenging and antioxidant activity, resulting from the presence of some flavonoids and phenolic compounds in the extracts.
Ethanol, hepatoprotective activity, leaf extracts, tylophora indica. Investigations on hepatoprotective activity of leaf extracts. The methanolic extracts, comparable to silymarin as a conventional drug, exhibited a higher hepatoprotective activity 25. Hepatoprotective effect of aqueous extracts of some medicinal. The hepatoprotective activity was studied by observing the effect of these herbal extracts on tbh induced reduction in cell viability of hepg2 cells. The goal of the present study was to examine the antioxidant and hepatoprotective activity of some medicinal. This study investigates the comparative hepatoprotective activity of crude ethanol extracts of cuscuta australis against acetaminophen apap intoxication. Pdf hepatoprotective activity of some plants extract against. Srinivasa rao, mohammed fazil ahmed and mohammed ibrahim abstract the aim of the study is to investigate the hepatoprotective activity of melia azedarach leaves extracts against simvastatin induced hepatotoxicity. This present investigation was aimed to assess the hepatoprotective activity of aqueous and ethanol extract of pongamia pinnata leaves against acetaminopheninduced liver damage in albino rats. In vitro antiviral activity of fifteen plant extracts against.
This plant can be considered as new biosource of hepatoprotective drugs. The use of plant extracts in therapy dates back many years. Hepatoprotective activity of solanum nigrum extracts on. The present study was carried out to screen and evaluate the hepatoprotective activity of leaf extracts of aegle marmelos l. The present study was conducted to evaluate the hepatoprotective activity of methanolic extract of whole plant of pulicaria. A lot of herbal plants and polyherbal formulations are used for the treatment of liver diseases. Ten groups of rats n 6 were given a oncedaily administration of 10% dimethyl sulfoxide negative control, 200 mgkg silymarin positive control, or memm 50, 250, or 500 mgkg for 7 days followed by induction of.
This suggests a hepatoprotective activity endowed in this plant. This work screened the hepatoprotective and antioxidant activity of ethanol ers, and aqueous ars, extracts of leaves of raphanus sativus in carbon tetrachloride ccl4, model in rats. Plant extracts have been commonly used over the years for the treatment and prevention of chronic and acute diseases, and health promotion. In the in vivo study, the hepatoprotective activity of a hydroalcoholic extract of anogeissus latifolia was analyzed in liver injured ccl 4treated rats. To evaluate the hepatoprotective activity of aqueousethanol 30. Srinivasa rao, mohammed fazil ahmed and mohammed ibrahim. The selected plant extracts had a virucidal effect and inhibited viral replication compared to the virus control p immunomodulatory and antibacterial effects of selected malaysian medicinal plant extracts mohammed abdullah mahdi alshawsh thesis submitted in fulfilment of the requirements for the degree of doctor of philosophy faculty of medicine university of malaya kuala lumpur 20.
The edible tuber part of the plant is a very common vegetable among indian people though maximum focus of research was done with the nonedible leaf part of the plant. The hepatoprotective effects of solanum nigrum water and methanolic extracts were studied in rats injected with 0. Hepatoprotective activity of methanol extract of melastoma. Different medicinal herbs and plants extracts have potent hepatoprotective activity in various animal models. Hepatoprotective activity of ethanolic extract of salix subserrata against ccl4induced chronic. Plants contain active constituents known as phytochemicals, which have been tested for their hepatoprotective potential in many parts of the world. Antioxidant activity dpph assay the antioxidant activity of the solvent extracts of the plant and the standard was determined by dpph method 39.
The extracts were subjected to antioxidant tests total reducing power and total phenolic content, and preliminary phytochemical. There is area for further study to characterize the active principle responsible for the hepatoprotective activity of the plant. It is again interesting to highlight that we have previously demonstrated that the leaves of b. The genus amaranthus has potential activity as a hepatoprotective agent. Thus the antioxidant activity of the ethanolic extract may be due to the presence of flavonoid and phenolic compounds. In vitro antioxidant and hepatoprotective activity. Hepatoprotective activities of ethanolic and aqueous extracts of a. In each well, 100 l of each extract dilution was mixed with 100 table 1. Hepatotoxicity and the role of some herbal hepatoprotective plants. Dixit, neelesh malviya and vijay ambawatia department of pharmacognosy, smriti college of pharmaceutical education, dewas naka, indore, madhya pradesh 452010 india abstract.
Tanninrich extracts from lannea stuhlmannii and lannea. World health organization traditional medicine strategy, geneva. The model used was carbon tetrachloride ccl 4 induced acute hepatotoxicity in albino rats. Agrawal, hepatoprotective activity of emebelia ribes against paracetamol induced acute hepatocellular damage in mice, experimental medicine, 2003, vol. Hepatoprotective and antioxidant effect of stem barks. The effect of chloroform fraction and methanol extracts of stem of calycopteris floribunda on ccl4 induced liver damage in rats with reference to biochemical. In vitro antioxidant and in vivo hepatoprotective activity of. The value was found to be comparable to that of standard ascorbic acid and quercetin. Hepatoprotective activity of the extract of homalium. In early study we have shown that peptides obtained from 7 plantain plantago major l. About 600 commercial herbal formulations with hepatoprotective activity are being sold all over the world.
Recent experience has shown that plant drugs are nontoxic, safe and even free from side effects 4. In vitro and in vivo hepatoprotective activity of extracts of. Hepatoprotective and antioxidant activity of standardized. Leaf powder of tylophora indica was successively extracted with alcohol and water. In vitro antiviral activity of twentyseven medicinal plant. Salix caprea is a plant that belongs to the salicaceae family. Antimicrobial activity of some plant extracts having hepatoprotective effects ammara hassan, salma rahman, farah deeba and shahid mahmud applied chemistry research centre, pcsir labs. Alocasia indica araceae is traditionally used in the treatment of abdomen and spleen related disorders. A number of studies have shown that the plant extracts having antioxidant activity protect against ccl 4 hepatotoxicity by inhibiting lipid peroxidation and enhancing antioxidant enzyme activity 45, 42, 21, 24,46 and38. In the present study, administration of ethanolic extract at doses of 50, 100 and 200 mgkg body weight to ccl 4 intoxicated rats caused a significant increase in the level of gsh 35. Antioxidant and hepatoprotective activity of ethanolic. Hepatoprotective plantsandrographis lineata neeshepatoprotective effect of andrographis lineata acanthaceae extracts in ccl4. The present study aimed to determine the hepatoprotective activity of a methanol extract of melastoma malabathricum leaves memm using two established rat models.
The plant ruellia tuberosa linn leaves was extracted with various solvent by using soxhlet apparatus. Anthocyanin characterization of pilot plant water extracts of delonix regia flowers. Aqueous and alcoholic extracts of terminalia catappa were taken. Medicinal plants with hepatoprotective activity in iranian. The selected plant extracts had a virucidal effect and inhibited viral replication compared to the virus control p hepatoprotective activity of alcoholic allt and aqueous aqlt extracts of leaves of tylophora indica asclepiadaceae against ethanolinduced hepatotoxicity. The phytochemical screening was done by the all extracts of. Hepatoprotective activity of the ethanolic extract of ficus. These plants and their extracts are being used as natural sources to treat various. Carbon tetrachloride, hepatoprotection, paracetamol, psidium guajava, thioacetamide liver diseases, such as jaundice, cirrhosis and fatty liver are very common worldwide. Use of plant derived drugs in medical practice has shown that they are relatively nontoxic, safe and free from serious side effects 6. The present results agree with previously reported data gupta et al.
In our research, we decided to demonstrate that peptides isolated from anethum graveolens l. Phytochemical screening and hepatoprotective effect of alhagi. In addition, the reducing power of the extracts and their ability to scavenge free radicals were evaluated using two antioxidant assay systems. Hepatoprotective activity of methanol extract of aerial parts. Antioxidant and hepatoprotective effects of croton. Antioxidant and hepatoprotective effects of solanum xanthocarpum leaf extracts against ccl4induced liver injury in rats behrouz jalali ghassam, hadi ghaffari, h. Hepatoprotective activity of melia azedarach leaf extract against. Further supportive evidence is rendered by the observation that the necrotic lesions were also reduced in rats given both extracts.
List of medicinal plants used in this work with the popular uses in uruguay. Hepatoprotective activity of melia azedarach leaf extract against simvastatin induced hepatotoxicity a. Hepatoprotective and cardiac inhibitory activities of. Hepatoprotective activity of elytraria acaulis plant extracts.
The results of this study indicate that extracts of leaves and plants extracts of some medicinal plant have good potentials for use in hepatic disease. Hepatoprotective effect of the solvent extracts of viola. Accepted 19 december 2008 the antimicrobial activity of hot water and ethanolic extracts of six plant extracts, utilized. One of the major source of natural products are plants. The extracts were prepared by the elytraria acaulis whole plant extracts in ethanol and aqueous solvents through maceration technique. Prakash, and kukkundoor ramachandra kini pharmaceutical biology downloaded from by mcmaster university on 101614 for personal use only. There are many plants and traditional formulations available to treat the liver diseases 5, 6. Hepatoprotective activity of aerial part and root extracts of. Its hepatoprotective activity is attributed to its antioxidant properties. Comparative hepatoprotective activity of ethanolic extracts. Hepatoprotective activity of the ethanolic extract of. Hepatoprotective activity of the medicinal plants name of plant source or family plant parts used hepatotoxic inducing agents extracts studied biochemical and histopathological parameters studied boerhaavia diffusa. Research article open access hepatoprotective effect of the. Evaluation of the hepatoprotective activity of fagonia.
The present study deals with hepatoprotective activity observed with ethanolic extracts of plant leaves and leaf callus of eclipta alba l. Keeping this view in the mind, bark extracts of terminalia catappa was selected for to evaluate the hepatoprotective activity. Hepatoprotective and antioxidant activity of ethanolic. Hepatoprotective effect of methanolic and aqueous extracts ofazadirachta indica leaves was evaluated using male wistar rats. Hepatoprotective activity of some indigenous plants. Tpc and tfc of methanol extract were higher than those of the aqueous extract. Hepatoprotective activity of extracts from stem of.
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